On road used 1690 by Spanish explorer Alonso de Leon. In 1821 Andrew Millican began settlement. Henry Fanthorp opened his inn 1834, a post office 1835. Kenneth Anderson, last Vice-President, Republic of Texas, died at Fanthorp's, 1845. After his burial here, town was named for him.
County created and organized 1846. Named in honor of Jesse Grimes (1788-1866), a signer of Declaration of Independence and member of Congress, Republic of Texas.
Anderson was made the county seat.
During Civil War, 1861-1865, had a gun factory, furnished troops, food, cotton.
(1965)
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