Goodall Harrison Wooten (1869-1942) was born in Paris, Texas, the son of Confederate veteran Dr. Thomas Dudley Wooten and his wife, Henrietta Goodall Wooten. Goodall Harrison Wooten attended the University of Texas, where he earned Bachelor's and Master's degrees; and Columbia University, where he received a medical degree in 1895. He established a medical practice in Austin, and in 1897 married Ella Newsome (1878-1972).
Construction of this house began in 1898 and was completed in January 1900. Designed by Dallas architect Charles O'Connell, it soon became an Austin landmark and was known for the extensive gardens planted by Ella Wooten. Renovations in 1910 changed the simple house into a grand Classical Revival mansion, and it remains one of the premiere examples of that style in Austin.
Prominent features of the Goodall Wooten House include its handsome brick and stonework, wrap-around gallery, balustrade, and massive two-story paired columns with ionic capitals. It is typical of the large-scale homes built in this neighborhood at the turn of the century. The house remained in the Wooten family until 1944.