By Act of Assembly St. Mark's Parish was established in 1757. The first Church stood at Halfway Swamp. Others were built near Williamsburg-Sumter Line, near Rimini, and near this site. These four churches were abandoned or burned. Soldiers and Patriots of the Revolution were members of St. Mark's Parish.
The present church, designed by Edward C. Jones and Francis D. Lee, of Charleston, was built of brick made of local clay, on land given by R.C. Richardson and R.I. Manning. The cornerstone was laid by Bishop Thos. F. Davis, Feb., 1854, and the church consecrated March, 1855. Six Governors and many noted citizens worshipped here.